Key Points about FGF23:

Protein Characteristics

• Fibroblast growth factor family member
• Produced by bone osteocytes and osteoblasts
• Regulates phosphate and calcium balance

Mechanism of Action

• Binds to receptors in kidneys and parathyroid glands
• Promotes phosphate excretion
• Reduces vitamin D production
• Suppresses PTH levels

Physiological Role

• Maintains phosphate homeostasis
• Prevents phosphate overload

Clinical Implications

• Chronic Kidney Disease
• X-Linked Hypophosphatemia
• Tumor-Induced Osteomalacia
• Cardiovascular Disease
• Genetic disorders

Potential Therapeutic Targets

• Modulating FGF23 activity
• Managing phosphate metabolism
• Mitigating adverse effects in kidney diseases

Key Functions

• Phosphaturia
• Inhibiting phosphate reabsorption
• Regulating vitamin D synthesis

FGF23 is a critical hormone in maintaining mineral balance and metabolism, with significant implications for kidney and bone health.