TSG101: Tumor Susceptibility Gene 101 Protein and Its Role in Cellular Processes
26-01-2025
TSG101 Summary:
Structure:
- 101 kDa protein
- Located on chromosome 11
- Contains UEV domain
Key Cellular Functions:
- Protein sorting/trafficking
- Cell cycle regulation
- Viral budding processes
Cancer Biology:
- Potential tumor suppressor
- Influences cell adhesion/migration
- Possible cancer biomarker
- Impacts tumor proliferation/metastasis
Viral Interactions:
- Critical in HIV protein packaging
- Assists viral budding
- Involved with Ebola, vesicular stomatitis viruses
Therapeutic Potential:
- Cancer treatment targeting
- Potential antiviral strategies
- Biomarker development
Research Focus:
- Restoring TSG101 function
- Blocking viral protein interactions
- Understanding cellular mechanisms
Significance: Multifunctional protein crucial in cellular processes, cancer progression, and viral pathogenesis.
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