Substance P Summary:

Molecular Structure:

• 11-amino acid neuropeptide
• From TAC1 gene
• Binds neurokinin-1 receptor (NK1R)

Key Functions:

• Pain signal transmission
• Inflammatory response regulation
• Neurotransmitter/neuromodulator

Pain Mechanisms:

• Amplifies pain signal sensitivity
• Involved in acute/chronic pain
• Triggers inflammatory responses

Inflammatory Involvement:

• Impacts asthma
• Increases vascular permeability
• Influences rheumatoid arthritis
• Affects digestive system disorders

Neuropsychiatric Connections:

• Linked to stress responses
• Potential depression biomarker
• May influence schizophrenia development

Therapeutic Potential:

• NK1R antagonist medications
• Pain relief strategies
• Biomarker diagnostic applications
• Exploring novel treatment pathways

Research Focus:

• Pain management
• Inflammation control
• Mental health interventions
• Neuropeptide signaling pathways

Significance: Complex neuropeptide with multisystem physiological impacts.