Key Summary of SIRT1:

Molecular Structure: NAD+ dependent deacetylase enzyme with catalytic core and regulatory domains. Moves between nucleus and cytoplasm.

Metabolic Functions:

• Regulates glucose and fatty acid metabolism
• Controls mitochondrial development
• Manages energy homeostasis across tissues
• Interacts with key metabolic proteins

Aging and Longevity:

• Enhances DNA repair
• Reduces cell senescence
• Controls stress response pathways
• Supports cellular resilience

Disease Implications:

1. Potential treatment for:

• Cardiovascular diseases
• Neurodegenerative conditions
• Cancer
• Metabolic disorders
• Age-related muscle disorders

2. Therapeutic Potential:

• Developing targeted activation compounds
• Improving insulin sensitivity
• Reducing inflammation
• Protecting against cellular stress

SIRT1 is a critical regulator of metabolism, aging, and potential disease interventions.