Key Points about Sequestosome-1 (P62/SQSTM1):

Structural Characteristics:

• 62 kilodalton protein
• Multiple functional domains
• Enables protein interactions and autophagy
• Found on chromosome 5

Autophagy Functions:

• Connects proteins with autophagy mechanisms
• Facilitates protein breakdown
• Helps remove damaged cellular components
• Regulates autophagic flux

Inflammatory Responses:

• Interacts with NF-kappa B signaling
• Activates NLRP3 inflammasome
• Manages oxidative stress responses

Neurodegenerative Disease Involvement:

• Accumulates in Alzheimer's and Parkinson's
• Associated with protein aggregation
• Contributes to neuroinflammation

Cancer Dynamics:

• Dual role as tumor suppressor/oncogene
• Can break down cancer-causing proteins
• Potential biomarker for tumor progression
• Influences cell growth and survival

Significant Research Areas:

• Protein quality control
• Cellular stress management
• Potential therapeutic targeting
• Understanding disease mechanisms