Molecular Structure and Classification:

• Member of class 3 semaphorin family
• Secreted protein for cellular signalling and guidance
• Structure includes:
• Sema domain
• PSI domain
• Immunoglobulin-like domain
• Interacts with neuropilin-2 and plexin family receptors

Physiological Functions and Signalling:

• Neuronal Development:
• Axon guidance and pathfinding
• Neuronal migration regulation
• Synaptic plasticity modulation
• Vascular System:
• Angiogenesis regulation
• Endothelial cell control
• Vascular patterning
• Immune System:
• Immune cell migration
• Inflammatory response modulation
• Immune surveillance

Role in Disease and Development:

• Cancer Biology:
• Tumor angiogenesis regulation
• Cancer cell migration/invasion
• Metastatic potential modification
• Developmental Processes:
• Embryonic vasculature formation
• Neural circuit establishment
• Organ system development
• Pathological Conditions:
• Cardiovascular diseases
• Neurological disorders
• Inflammatory conditions

Therapeutic Applications and Clinical Relevance:

• Cancer Therapy:
• Anti-angiogenic strategies
• Metastasis prevention
• Combination therapy
• Regenerative Medicine:
• Neural tissue repair
• Vascular regeneration
• Wound healing
• Disease Biomarkers:
• Diagnostic applications
• Progress monitoring
• Treatment response evaluation

Future Research Directions:

• Mechanism Investigation:
• Signalling pathway analysis
• Receptor complex interactions
• Tissue-specific functions
• Therapeutic Development:
• Drug design strategies
• Delivery system optimization
• Clinical trial planning
• Diagnostic Applications:
• Biomarker development
• Screening methods
• Patient stratification