SAA4: The Constitutive Serum Amyloid A Protein in Health and Disease
Endocrinology Diagnostics
Key Summary of SAA4 (Serum Amyloid A-4):
Molecular Structure: Unique constitutive SAA protein encoded by SAA4 gene. Features amphipathic α-helical regions, primarily produced in the liver with extra-hepatic expression.
Physiological Functions:
- Lipid transport and metabolism
- Interactions with HDL particles
- Tissue restructuring and restoration
- Cell signaling and receptor interactions
Lipid Metabolism: Helps:
- Remove cholesterol from cells
- Transport lipids
- Modify HDL particle composition
- Regulate cellular lipid uptake and release
Clinical Implications:
- Potential role in cardiovascular diseases
- Possible biomarker in metabolic disorders
- Links to inflammatory conditions
- Interest in diabetes and obesity research
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