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Ribonuclease T2 (RNASET2): A Conserved Endonuclease with Diverse Biological Functions and Clinical Implications

Endocrinology Diagnostics

Key Summary of Ribonuclease T2 (RNASET2):

Molecular Structure

  • T2 ribonuclease with unique enzymatic properties
  • Conserved histidine residues and CAS motifs
  • Functions optimally in acidic cellular environments

Physiological Functions

  • Involved in RNA metabolism
  • Supports cellular quality control
  • Aids in autophagy and neuronal development

Immune System Role

  • Influences macrophage and dendritic cell activation
  • Assists in stress response and tissue repair
  • Regulates inflammatory pathways

Pathological Implications

  • Deficiency causes neurological developmental issues
  • Acts as tumor suppressor
  • Linked to various cancer progressions

Clinical Potential

  • Emerging marker for neurological disorders
  • Potential therapeutic target
  • Future research focuses on:
    • Enzyme replacement
    • Gene therapy strategies
    • Precision treatment methods
ENQUIRY FORM

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