Key Points about Protein Wnt-7a (WNT7A):

Molecular Structure:

• Secreted glycoprotein
• 349 amino acids
• Post-translational modifications crucial for function
• Binds Frizzled and LRP5/6 receptors

Signaling Mechanisms:

• Activates canonical β-catenin pathway
• Triggers complex intracellular events
• Context-dependent signaling
• Involves receptor complexes and protein interactions

Developmental Functions:

• Limb axis patterning
• Synaptic differentiation
• Reproductive tract formation
• Muscle stem cell regulation

Pathological Associations:

• Developmental abnormalities
• Fuhrmann syndrome
• Cancer progression
• Neurodegenerative conditions
• Skeletal muscle disorders

Therapeutic Potential:

• Recombinant protein therapy
• Small molecule modulators
• Gene therapy strategies
• Cancer treatment

Regenerative medicine applications