Key Points about Peptide YY (PYY):

Basic Overview:

• 36-amino acid hormone produced in intestinal L-cells
• Primarily regulates appetite, metabolism, and gastrointestinal functions
• First identified in the 1980s

Structure and Production:

• Originates from pro-PYY precursor
• Two main variants: PYY1-36 and PYY3-36
• Released in response to nutrient intake

Mechanism of Action:

• Binds to Y2 and Y1 receptors in brain and peripheral tissues
• Y2 receptor interaction suppresses appetite by inhibiting hunger-stimulating neuropeptides
• Reduces food consumption and induces fullness

Physiological Roles:

• Appetite suppression
• Slows gastrointestinal motility
• Regulates gut hormones
• Potentially influences insulin secretion
• May impact energy expenditure

Relevance to Obesity and Metabolic Disorders:

• Altered effectiveness in obese individuals
• Potential therapeutic target for weight management
• Research exploring PYY analogues and combination therapies
• Interactions with gut microbiota being investigated

Future Research:

• Developing synthetic PYY versions
• Exploring combination hormone therapies
• Understanding metabolic syndrome connections