Oxidized High-Density Lipoprotein (OxHDL): From Molecular Modifications to Pathophysiological Implications in Cardiovascular Disease
Endocrinology Diagnostics
Key Summary of Oxidized High-Density Lipoprotein (OxHDL):
Molecular Structure
- Formed through oxidative modifications
- Targets apolipoprotein A-I
- Involves lipid peroxidation
Oxidation Mechanisms
- Triggered by myeloperoxidase system
- Influenced by metal ions
- Accelerated by environmental factors
Functional Consequences
- Reduces cholesterol efflux capacity
- Impairs anti-inflammatory properties
- Compromises antioxidant capabilities
Cardiovascular Impact
- Linked to atherosclerosis progression
- Encourages plaque formation
- Affects platelet function and blood clotting
Clinical Significance
- Potential cardiovascular disease risk indicator
- Emerging therapeutic approaches include:
- Preventing HDL oxidation
- Developing oxidation-resistant HDL
- Neutralizing oxidized components
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