OGG1 (8-Oxoguanine DNA Glycosylase): Guardian of Genomic Integrity
Endocrinology Dignostics
Key Points about OGG1 (8-Oxoguanine DNA Glycosylase):
Protein Characteristics
- DNA repair enzyme
- Base excision repair (BER) specialist
- Removes oxidative DNA damage
Structural Features
- Helix-hairpin-helix superfamily
- Two main domains
- Glycosylase and lyase activities
Primary Functions
- Repair 8-oxoguanine DNA damage
- Prevent mutation accumulation
- Maintain genomic stability
- Protect against oxidative stress
Disease Associations
- Increased cancer risk
- Linked to neurodegenerative diseases
- Contributes to aging-related conditions
Enzymatic Mechanism
- Cleaves damaged DNA bases
- Creates single-strand breaks
- Initiates DNA repair process
Research Directions
- Exploring function control
- Investigating non-repair roles
- Developing treatment approaches
OGG1 is a critical enzyme protecting genomic integrity and potentially influencing various disease processes.
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