Basic Structure and Function

• Part of neurofilament protein network
• Maintains neuron health and operation
• Works with NEFM and NEFH proteins
• Supports neuronal cytoskeleton structure
• Helps regulate axon diameter

Role in Neural Health

• Forms polymer chains moving along axons
• Supports axon growth and repair
• Released into surrounding environment when neurons damaged
• Detectable in cerebrospinal fluid and blood
• Essential for electrical signal transmission

Biomarker Applications

• Indicates brain damage without invasive tests
• Higher levels linked to Alzheimer's progression
• Shows disease severity in ALS patients
• Helps distinguish MS types
• Enables non-invasive disease monitoring

Diagnostic Value

• Can be measured through sensitive blood tests
• Complements other biomarkers like amyloid and tau
• Helps track disease progression
• Aids in treatment effectiveness monitoring
• Valuable for early disease detection

Future Potential

• Promising for early intervention strategies
• Could help develop new therapeutic approaches
• Potential for preventive screening
• May assist in treatment development

Useful for monitoring treatment effectiveness