Basic Function and Role

• Key enzyme in NAD+ biosynthesis
• Converts nicotinamide and PRPP into nicotinamide mononucleotide
• Essential for DNA repair and metabolism
• Exists in intracellular (iNAMPT) and extracellular (eNAMPT) forms

Metabolic Disease Impact

• Strongly connected to besity and type 2 diabetes
• Higher tissue levels linked to insulin resistance
• Influences inflammatory responses
• Plays dual role in metabolism and metabolic disorders
• Important for energy balance maintenance

Aging and Neurodegeneration

• NAD+ levels decrease with age
• Critical for neuron function and energy production
• Affects cellular resilience during aging
• Linked to conditions like Alzheimer's and Parkinson's
• Shows potential for extending lifespan

Therapeutic Applications

• NAD+ precursors can boost NAD+ levels
• NMN supplements show promise for metabolism
• NAMPT inhibition potential for cancer treatment
• FK866 and other inhibitors under clinical trials
• Important for improving cognitive function

Research Challenges

• Balance needed in cancer treatment approaches
• Toxicity concerns with NAMPT inhibitors
• Complex tissue-specific functions
• Need to maintain normal cell function
• Ongoing research for safe, effective treatments