Mucin-1 (MUC-1): A Multifunctional Glycoprotein in Health and Disease
Endocrinology Diagnostics
Key Points about Mucin-1 (MUC-1):
Protein Characteristics
- Glycoprotein located on chromosome 1
- Expressed in epithelial cells
- Protective mucosal barrier function
Structural Features
- Repetitive amino acid patterns
- Transmembrane segment
- Cytoplasmic signalling capabilities
Biological Functions
- Mucosal protection
- Cell communication
- Tissue hydration
- Immune system interaction
Disease Associations
- Cancer biomarker
- Tumor progression
- Inflammatory disorders
- Autoimmune conditions
Therapeutic Potential
- Cancer immunotherapy
- Targeted drug delivery
- Antibody development
- Disease progression monitoring
Mechanisms
- Barrier formation
- Cell signalling
- Immune cell recognition
- Pathogen prevention
MUC-1 is a critical glycoprotein with complex roles in tissue protection, cellular communication, and disease progression.
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