LXR-Alpha: Key Regulator of Lipid Metabolism and Inflammation

Structure:

• Nuclear receptor with DNA and ligand binding domains
• Activated by oxysterols
• Identifies specific DNA response elements

Physiological Roles:

• Cholesterol management
• Lipid metabolism regulation
• Bile acid production
• Cholesterol transport
• Macrophage cholesterol removal

Disease Implications:

• Atherosclerosis development
• Cancer progression
• Potential Alzheimer's disease involvement
• Metabolic disorder links

Therapeutic Potential:

• LXR activators for: Atherosclerosis treatment, Inflammatory disease management
• Challenges include liver fat production side effects

Research Strategies:

• Targeted intestinal LXR activators
• Combination receptor modulators
• Advanced delivery techniques
• Precise targeting approaches

Transcriptional Interactions:

• Collaborates with nuclear receptors
• Influenced by RXRs, PPARs, FXRs
• Regulated by post-translational modifications
• Connects metabolism with biological clock proteins