Key Summary of IGSF11:

Structural Overview

• Immunoglobulin superfamily protein
• Cell surface protein with membrane and cytoplasmic components
• Also known as PVRL3

Immune Response Functions

• Influences T cell activation
• Regulates immune cell interactions
• Supports cytokine production
• Controls T cell development

Autoimmunity Implications

• Associated with systemic lupus erythematosus
• Linked to rheumatoid arthritis
• Impacts immune tolerance
• Potential role in regulatory T cell development

Cancer Interactions

• Present in lung cancer and melanoma
• Influences tumor microenvironment
• Potential immune suppression mechanism
• Possible prognostic indicator

Research Potential

• Target for immune system modulation
• Promising avenue for therapeutic interventions
• Requires further investigation in disease contexts