Key Points about Inducible Nitric Oxide Synthase (iNOS/NOS2):

Protein Characteristics

• Enzyme in nitric oxide synthase family
• Encoded by NOS2 gene
• Triggered during inflammatory responses

Structural Components

• Oxygenase domain
• Flavin binding sites
• Calmodulin-regulated activity

Activation Mechanisms

• Stimulated by pro-inflammatory cytokines
• Activated by pathogen molecular patterns
• Responsive to oxidative stress

Immune System Functions

• Generates nitric oxide
• Antimicrobial activity
• Inflammation regulation
• Apoptosis control

Pathological Implications

• Linked to rheumatoid arthritis
• Associated with neurodegenerative diseases
• Potential cancer progression
• Contributes to cardiovascular disorders

Therapeutic Potential

• Targeted drug development
• Nitric oxide modulation
• Gene therapy approaches
• Combinatorial treatment strategies

iNOS is a critical enzyme in immune response, with complex roles in health and disease progression, offering significant potential for medical interventions.