IL20RA (Interleukin-20 Receptor Subunit Alpha): A Key Player in Inflammatory Signalling
Immunology / Cytokines
Key Points about IL20RA:
Protein Structure
- Type I transmembrane protein
- Extracellular cytokine binding domain
- Expressed in skin, lung, immune cells
Receptor Complex Formation
- IL20RA/IL20RB complex
- IL20RA/IL10RB complex
- Mediates inflammatory responses
Signalling Pathways
- JAK/STAT cascade
- MAP kinase pathway
- Regulates inflammatory gene expression
Clinical Significance
- Inflammatory conditions
- Immune response regulation
- Psoriasis
- Rheumatoid arthritis
Therapeutic Potential
- Monoclonal antibody targeting
- Small molecule inhibitors
- Autoimmune disorder treatment
- Chronic inflammatory conditions
Research Developments
- Novel regulatory mechanisms
- Single-cell analysis
- Structure-based drug design
- Biomarker development
IL20RA serves as a critical receptor in inflammatory signalling with significant implications for disease understanding and treatment.
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