Furin: A Critical Cellular Protease in Health and Disease
Endocrinology Diagnostics
Key Points about Furin:
Protein Overview
- First PCSK family member
- 794 amino acid zymogen
- Multiple structural domains
- Primarily located in trans-Golgi network
Activation Mechanism
- Autocatalytic process
- Involves prodomain removal
- Cycles through cellular compartments
Substrate Recognition
- Specific consensus sequence: R-X-K/R-R
- Processes various proteins including:
- Growth factors
- Hormones
- Cell surface receptors
- Viral proteins
Disease Implications
- Cancer progression
- Viral infection mechanisms
- Bacterial protein processing
Physiological Functions
- Protein modification
- Cell signaling
- Enzyme processing
- Cellular homeostasis maintenance
Therapeutic Potential: Inhibitor development targeting:
- Cancers
- Viral infections
- Bacterial infections
- Metabolic disorders
Furin is a critical protease with complex cellular roles and significant potential for medical interventions across multiple disease domains.
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