Key Summary of Fractalkine (CX3CL1):

Molecular Structure

• Unique CX3C chemokine with membrane-bound and soluble forms
• Influenced by inflammatory cytokines
• Capable of acting as adhesive agent and chemical attractant

Signaling Mechanisms

• Interacts with CX3CR1 receptor
• Activates pathways like PI3K/Akt and ERK
• Enables cell adherence in blood vessels and nerve tissues

Disease Involvement

• Contributes to inflammatory disorders
• Impacts neurodegenerative diseases
• Influences cardiovascular disease progression
• Affects cancer cell migration and survival

Therapeutic Potential

• Emerging drug development strategies
• Potential therapies include:
• Antibodies against Fractalkine
• Receptor blockers
• Targeted molecular interventions

Unique Characteristics

• Complex post-translational modifications
• Dual functionality in cellular interactions

Critical in immune and inflammatory responses