Introduction

• Protein involved in membrane microdomain organization
• Associated with lipid rafts
• Rafts contain cholesterol and sphingolipids
• Acts as platforms for cellular processes:
• Signalling
• Membrane trafficking
• Cell adhesion
• Supports structural integrity of lipid rafts

Structure and Function Structure:

• Contains conserved flotillin domain
• Has specific end-terminal domain
• Forms homodimers
• Essential for lipid raft formation

Functions:

• Assists in membrane protein absorption
• Facilitates endocytosis
• Helps protein clustering in lipid rafts
• Supports protein transport to endosomal regions

Role in Cellular Processes Signal Transduction:

• Interacts with receptor tyrosine kinases (RTKs)
• Works with G protein-coupled receptors (GPCRs)
• Facilitates receptor clustering in lipid rafts
• Connects with:
• Src family kinases
• Phospholipase C
• Influences:
• Cell growth
• Differentiation
• Survival

Cellular Adhesion and Migration:

• Promotes cell-cell connections
• Strengthens cell-matrix interactions
• Increased expression linked to cancer cell migration
• Potential therapeutic target for preventing cancer invasion

Implications in Disease Cancer:

• Associated with multiple cancer types:
• Breast cancer
• Colon cancer
• Prostate cancer
• Supports tumor cell growth and survival
• Expression levels may indicate:
• Disease progression
• Treatment response

Neurodegenerative Diseases:

• Involved in amyloid precursor protein processing
• Affects amyloid beta peptide formation
• Relevant to Alzheimer's disease development
• Potential therapeutic target for brain disorders