GPT (Alanine Aminotransferase 1) Summary:

Core Function:

• Enzyme crucial for amino acid metabolism
• Converts alanine and α-ketoglutarate
• Primarily located in liver
• Regulates nitrogen metabolism and gluconeogenesis

Clinical Significance:

• Key biomarker for liver health
• Elevated levels indicate liver cell damage
• Used to diagnose conditions like:
• Hepatitis
• Fatty liver disease
• Liver cirrhosis

Regulatory Factors: Influenced by:

• Diet
• Hormone levels
• Metabolic health
• Insulin
• Stress hormones

Pathophysiological Implications: Linked to:

• Obesity
• Type 2 diabetes
• Metabolic syndrome
• Insulin resistance
• Non-alcoholic fatty liver disease (NAFLD)

Research and Therapeutic Potential:

• Exploring drugs to:
• Modulate enzyme activity
• Manage metabolic disorders
• Lifestyle interventions may impact GPT levels

Key Insight: GPT extends beyond liver function, serving as a critical indicator of broader metabolic health and potential disease progression.