Exploring the Role of Alanine Aminotransferase 1 (GPT) in Metabolism and Liver Function
Endocrinology Diagnostics
GPT (Alanine Aminotransferase 1) Summary:
Core Function:
- Enzyme crucial for amino acid metabolism
- Converts alanine and α-ketoglutarate
- Primarily located in liver
- Regulates nitrogen metabolism and gluconeogenesis
Clinical Significance:
- Key biomarker for liver health
- Elevated levels indicate liver cell damage
- Used to diagnose conditions like:
- Hepatitis
- Fatty liver disease
- Liver cirrhosis
Regulatory Factors: Influenced by:
- Diet
- Hormone levels
- Metabolic health
- Insulin
- Stress hormones
Pathophysiological Implications: Linked to:
- Obesity
- Type 2 diabetes
- Metabolic syndrome
- Insulin resistance
- Non-alcoholic fatty liver disease (NAFLD)
Research and Therapeutic Potential:
- Exploring drugs to:
- Modulate enzyme activity
- Manage metabolic disorders
- Lifestyle interventions may impact GPT levels
Key Insight: GPT extends beyond liver function, serving as a critical indicator of broader metabolic health and potential disease progression.
Suitable ELISA Kits
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