CCK Summary:

Molecular Structure:

• Peptide hormone
• Multiple bioactive forms (CCK-58, CCK-33, CCK-8, CCK-4)
• Synthesized on chromosome 3

Receptor System:

• Two receptor types: CCK-A and CCK-B
• G-protein coupled
• Distributed in gut and brain

Key Physiological Functions:

• Digestive regulation
• Gallbladder contraction
• Pancreatic enzyme secretion
• Appetite control
• Neurotransmitter
• Insulin release management

Clinical Significance: Associated with:

• Metabolic disorders
• Obesity
• Type 2 diabetes
• Anxiety disorders
• Pancreatic diseases
• Gallbladder conditions

Unique Characteristics:

• Produced in gut and brain
• Responds to dietary proteins/fats
• Delays stomach emptying
• Involved in pain processing
• Regulates inflammatory reactions

Diagnostic Potential:

• CCK stimulation tests
• Assessments of gallbladder function