Key Points about Chemerin:

Protein Characteristics

• 157 amino acid protein
• Produced by RARRES2 gene
• Activated by serine proteases
• Primarily binds to ChemR23 receptor

Biological Functions

• Adipogenesis and metabolic regulation
• Immune system signaling
• Inflammation control
• Glucose and insulin sensitivity management

Clinical Implications

• Linked to obesity and metabolic syndrome
• Associated with type 2 diabetes
• Indicates cardiovascular disease risk
• Connected to inflammatory conditions
• Potential role in cancer biology

Measurement

• Detected via ELISA methods
• Blood serum/plasma analysis

Therapeutic Potential

• Target for drug development
• Possible intervention in:
• Obesity
• Insulin resistance
• Cardiovascular diseases
• Inflammatory disorders

Future Research Directions

• Long-term disease progression studies
• Clinical trials on chemerin treatments
• Exploring biomarker applications
• Investigating varied disease interactions

Chemerin represents a complex biomarker with significant potential in understanding metabolic and inflammatory processes.