CD46/MCP: Cellular Protein with Multifaceted Immune Functions

Structure:

• Glycoprotein with four consensus repeats
• Regulates complement system
• Multiple protein isoforms

Key Functions:

• Prevents complement system damage to cells
• Influences T cell responses
• Controls inflammation
• Manages immune system balance

Pathogen Interactions:

• Receptor for viruses and bacteria
• Mediates cellular infection responses
• Balances host protection and pathogen invasion

Signalling Roles:

• Triggers cell behavior changes
• Impacts immune responses
• Influences autophagy
• Affects cellular metabolism

Cancer Implications:

• Regulates complement system in tumors
• Potential therapeutic target
• Can shield cancer cells from destruction

Therapeutic Potential:

• Antibody-based treatments
• Chimeric antigen receptor T cell strategies
• Promising for: Cancer immunotherapy, Autoimmune disorders, Infectious disease management

Ongoing research focuses on precise targeting and innovative treatment approaches leveraging CD46's complex immunological capabilities.