Caspase-1: Molecular Mechanisms, Inflammatory Regulation, and Therapeutic Implications in Innate Immunity and Disease
Endocrinology Diagnostics
Caspase-1 Summary:
Structure and Activation:
- Zymogen protein (pro-caspase)
- Activated within inflammasomes
- Contains CARD domain
- Requires specific structural rearrangement
Key Inflammatory Functions:
- Processes inflammatory proteins IL-1β and IL-18
- Triggers pyroptosis (programmed cell death)
- Cleaves Gasdermin D to form membrane pores
- Releases inflammatory cytokines
Inflammatory Mechanisms:
- Activated by pathogen and danger signals
- Involves ASC adaptor protein clustering
- Uses specific aspartate cleavage sites
- Modulated by post-translational modifications
Physiological Impacts:
- Promotes immune response
- Attracts neutrophils
- Stimulates natural killer and T-cell activity
- Helps eradicate pathogens
Therapeutic Potential:
- Target for inflammatory disease treatments
- Inhibition strategies under investigation
- Trials of caspase-1 inhibitors (e.g., VX-765)
- Focuses on modulating inflammasome formation
Significance: Critical molecular player in innate immune responses and inflammatory regulation.
Suitable ELISA Kits
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