Alpha-Lactalbumin (LALBA): A Multifunctional Protein in Lactation and Beyond
Endocrinology Diagnostics
Introduction:
- LALBA is a prominent whey protein in milk
- Contains 123 amino acids
- Essential for lactose production
- Has multiple biological functions including antimicrobial and immunomodulatory effects
Structure and Function:
- Member of α-lactalbumin protein group
- Structure includes tightly folded amino acid chain
- Held together by disulfide bonds
- Three-dimensional shape crucial for binding and lactose production regulation
Lactose Synthesis:
- Partners with β-1,4-galactosyltransferase (β-GalT)
- Facilitates galactose to glucose conversion
- Essential for lactose production
- Maintains milk osmotic balance
- Supports nutrient absorption
Role in Infant Nutrition:
- Makes up 25% of whey proteins in breast milk
- Easily absorbed and digested
- Provides essential amino acids for infant growth
- Promotes gut health
- Supports immune system development
- Helps establish healthy gut microbiome
Cancer Research:
- Shows potential anti-cancer properties
- Can inhibit growth of specific cancer cells
- May trigger cell death in breast cancer cells
- Affects cell signaling pathways related to growth and survival
Nutraceuticals and Food Industry:
- Used in dairy products and protein supplements
- Adds nutritional value to food products
- Popular in health-focused foods
- Promotes general wellness
Future Directions and Research:
- Investigating effects on obesity and inflammatory diseases
- Research on extraction and refinement methods
- Development of high-quality supplements
- Potential for engineered production processes
- Focus on increasing accessibility for research and commercial use
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